Organ Engineering Research －Lung , Airway－
T.Tsuchiya's Research Team in Toyama & Nagasaki University
土谷智史 臓器再生研究グループ －肺再生、気道再生－
ABOUT US
We are a research team in University of Toyama and Nagasaki University Graduate School of Biomedical Sciences. We have two main research projects.
1. Lung regeneration / Airway regeneration (Disease models using engineered organs)
Organ shortage is an urgent issue in organ transplantation. The fabrication of transplantable organs is one of the great challenges of modern medicine. We are investigating methods for tissue and organ engineering using decellularized scaffolds.
Further, engineered small organs fabricated from rat scaffolds are useful as disease models. We are developing ex vivo research tools such as cancer models.
2. Cell therapy in organ transplantation
In transplantation medicine, life-long immunosuppressants are necessary for preventing rejection. Mesenchymal stromal cells (MSCs) are known to suppress inflammation and immunoreactions. We are analyzing the mechanism of immunosuppressive effects of MSCs in lung transplantation models with the aim for clinical application.
私たちは富山大学と長崎大学医歯薬総合研究科の研究チームであり、2つの研究テーマを柱としています。
１．肺再生 / 気管再生（再生臓器を応用した疾患モデル）
移植医療において臓器不足は喫緊の課題であり、移植可能な再生臓器を作成することは、人類の夢です。私たちは、肺再生、気管再生を最終目標とし、脱細胞化組織骨格を利用した組織および臓器再生研究を行っています。
また、ラット組織骨格から創生した小型の再生臓器は、疾患モデルとして応用可能です。がんモデルなど、Ex vivoの新しい研究用材として開発中です。
２．細胞治療
移植医療では、移植された臓器の拒絶を防ぐため、生涯にわたる免疫抑制が必要です。間葉系幹細胞は抗炎症、免疫抑制作用があることが知られています。私たちは、脂肪由来間葉系幹細胞による肺移植時の免疫抑制効果の機序を解析し、臨床応用を目指しています。
GROUP MEMBERS
Tomoshi Tsuchiya
土谷 智史
Ryoichiro Doi
土肥良一郎
Hironosuke Watanabe
渡邊洋之助
Tomohiro Obata
小畑 智裕
MD. PhD.
Professor
Team Leader
Surgeon in the Department of Thoracic Surgery.
Department of Pathology & Gerontology (1998-2004)
Department of Biochemistry, University of California, Riverside, USA (2002-2004)
Biomedical Engineering Vascular Biology and Therapeutics, Yale University, USA (2011-2012)
University of Toyama (2021-)
Satoshi Mizoguchi
溝口 聡
MD. PhD.
Postdoctoral Fellow
Biomedical Engineering Vascular Biology and Therapeutics, Yale University, USA (2022-)
Surgeon in the Department of Surgical Oncology.
MD. PhD.
Assistant Professor
Surgeon in the Department of Surgical Oncology.
Columbia Center for Translational Immunology, USA (2017)
Nagasaki University (2018-)
Mitsutoshi Ishii
石井 光寿
MD. PhD.
Surgeon in the Department of Surgical Oncology.
MD. PhD.
Surgeon in the Department of Surgical Oncology.
Columbia Center for Translational Immunology, USA (2015-2018)
Nagasaki University (2019-)
Insurance Bureau
Assistant Director, Medical Division (2022-)
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Yuma Takamura
高村 祐磨
MD.
Graduate Student
Surgeon in the Department of Surgical Oncology.
MD. PhD.
Assistant Professor
Surgeon in the Department of Surgical Oncology.
Biomedical Engineering Vascular Biology and Therapeutics, Yale University, USA (2019-2021)
Nagasaki University (2022-)
Yukinori Tanoue
田上 幸憲
MD.
Graduate Student
Surgeon in the Department of Surgical Oncology.
Mary Durbin
Yutaka Maeda
前田 豊
PhD. (Genetics)
Department of Botany and Plant Sciences, University of California, Riverside (1974-2004)
Department of Ecology and Evolutionary Biology, University of California, Irvine (2004-2011)
English Editing and Assistance
DVM, PhD.
Assistant Professor
Adviser on Foreign Affairs
UC Department of Pediatrics.
Cincinnati Children's Hospital Medical Center
Naoya Kitamura
北村 直也
MD.
Graduate Student
Surgeon in the Department of Thoracic Surgery.
University of Toyama (2021-)