ABOUT US

We are a research team in Nagasaki University Graduate School of Biomedical Sciences. We have two main research projects.

 

1. Lung regeneration / Airway regeneration (Disease models using engineered organs)

    Organ shortage is an urgent issue in organ transplantation. The fabrication of transplantable organs is one of the great challenges of modern medicine. We are investigating methods for tissue and organ engineering using decellularized scaffolds.

    Further, engineered small organs fabricated from rat scaffolds are useful as disease models. We are developing ex vivo research tools such as cancer models.

2. Cell therapy in organ transplantation

    In transplantation medicine, life-long immunosuppressants are necessary for preventing rejection. Mesenchymal stromal cells (MSCs) are known to suppress inflammation and immunoreactions. We are analyzing the mechanism of immunosuppressive effects of MSCs in lung transplantation models with the aim for clinical application.

私たちは長崎大学医歯薬総合研究科の研究チームであり、2つの研究テーマを柱としています。

1.肺再生 / 気管再生(再生臓器を応用した疾患モデル)

 移植医療において臓器不足は喫緊の課題であり、移植可能な再生臓器を作成することは、人類の夢です。私たちは、肺再生、気管再生を最終目標とし、脱細胞化組織骨格を利用した組織および臓器再生研究を行っています。

 また、ラット組織骨格から創生した小型の再生臓器は、疾患モデルとして応用可能です。がんモデルなど、Ex vivoの新しい研究用材として開発中です。

2.細胞治療

​ 移植医療では、移植された臓器の拒絶を防ぐため、生涯にわたる免疫抑制が必要です。間葉系幹細胞は抗炎症、免疫抑制作用があることが知られています。私たちは、脂肪由来間葉系幹細胞による肺移植時の免疫抑制効果の機序を解析し、臨床応用を目指しています。

GROUP MEMBERS

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Tomoshi Tsuchiya

土谷 智史

Ryoichiro Doi

​土肥良一郎

Hironosuke Watanabe

渡邊洋之助

Tomohiro Obata

​小畑 智裕

MD. PhD.

Associate Professor

Team Leader

Surgeon in the Department of Surgical Oncology.

Department of Pathology & Gerontology (1998-2004)

Department of Biochemistry, University of California, Riverside, USA (2002-2004)

Biomedical Engineering Vascular Biology and Therapeutics, Yale University, USA (2011-2012)

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Satoshi Mizoguchi

溝口 聡

MD.

Graduate Student

Surgeon in the Department of Surgical Oncology. 

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Mary Durbin

​MD. PhD.

Assistant Professor

Surgeon in the Department of Surgical Oncology.  

Columbia Center for Translational Immunology, USA (2017)

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Mitsutoshi Ishii

石井 光寿

MD.

Graduate Student

Surgeon in the Department of Surgical Oncology. 

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Yutaka Maeda

MD. PhD.

Assistant Professor

Surgeon in the Department of Surgical Oncology.

Columbia Center for Translational Immunology, USA (2015-2018)

MD.

Postdoctoral Fellow in Yale Univ.

Biomedical Engineering Vascular Biology and Therapeutics, Yale University, USA (2019- )

Surgeon in the Department of Surgical Oncology.

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Yuma Takamura

高村 祐磨

MD.

Graduate Student

Surgeon in the Department of Surgical Oncology. 

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Yukinori Tanoue

田上 幸憲

MD.

Graduate Student

Surgeon in the Department of Surgical Oncology. 

​前田 豊

PhD. (Genetics)

Department of Botany and Plant Sciences, University of California, Riverside (1974-2004)

Department of Ecology and Evolutionary BiologyUniversity of California, Irvine (2004-2011)

English Editing and Assistance

DVM, PhD.

Assistant Professor

Adviser on Foreign Affairs

UC Department of Pediatrics.

Cincinnati Children's Hospital Medical Center