SELECTED PUBLICATIONS

2023

A novel ex vivo lung cancer model based on bioengineered rat lungs. Mizoguchi S, Tsuchiya T, Doi R, Obata T, Iwatake M, Hashimoto S, Matsumoto H, Yukawa H, Hayashi H, Li TS, Yamamoto K, Matsumoto K, Miyazaki T, Tomoshige K, Nagayasu T.

Front Bioeng Biotechnol. 2023 Jun 26;11:1179830. doi: 10.3389/fbioe.2023.1179830. eCollection 2023.PMID: 37434755 Free PMC article.

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Adipose-Derived Mesenchymal Stem Cells Attenuate Immune Reactions Against Pig Decellularized Bronchi Engrafted into Rat Tracheal Defects. Hisanaga M, Tsuchiya T, Watanabe H, Shimoyama K, Iwatake M, Tanoue Y, Maruyama K, Yukawa H, Sato K, Kato Y, Matsumoto K, Miyazaki T, Doi R, Tomoshige K, Nagayasu T.

Organogenesis. 2023 Dec 31;19(1):2212582. doi: 10.1080/15476278.2023.2212582.PMID: 37183703 Free PMC article.

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FOXA2 Cooperates with Mutant KRAS to Drive Invasive Mucinous Adenocarcinoma of the Lung. Tomoshige K, Stuart WD, Fink-Baldauf IM, Ito M, Tsuchiya T, Nagayasu T, Yamatsuji T, Okada M, Fukazawa T, Guo M, Maeda Y.

Cancer Res. 2023 May 2;83(9):1443-1458. doi: 10.1158/0008-5472.CAN-22-2805.

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2022

Donor and Recipient Adipose-Derived Mesenchymal Stem Cell Therapy for Rat Lung Transplantation.  Shimoyama K, Tsuchiya T, Watanabe H, Ergalad A, Iwatake M, Miyazaki T, Hashimoto Y, Hsu YI, Hatachi G, Matsumoto K, Ishii M, Mizoguchi S, Doi R, Tomoshige K, Yamaoka T, Nagayasu T.

Transplant Proc. 2022 Sep;54(7):1998-2007. doi: 10.1016/j.transproceed.2022.05.038.  Free PMC Article

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2021

Increased In Vitro Intercellular Barrier Function of Lung Epithelial Cells Using Adipose-Derived Mesenchymal Stem/Stromal Cells.  Ishii M, Tsuchiya T, Doi R, Morofuji Y, Fujimoto T, Muto H, Suematsu T, Mori R, Matsumoto K, Miyazaki T, Tomoshige K, Watanabe H, Iwatake M, Nagayasu T.

Pharmaceutics. 2021 Aug 16;13(8):1264. doi: 10.3390/pharmaceutics13081264. Free PMC Article

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2020

Lung Microvascular Niche, Repair and Engineering. Tsuchiya T, Doi R, Obata T, Hatachi G, Nagayasu T.

Frontiers Bioengineering and Biotechnology 2020. Review. Feb 21;8:105. doi: 10.3389/fbioe.2020.00105. Free PMC Article

 

2019

Alteration of the extracellular matrix and alpha-gal antigens in the rat lung scaffold reseeded using human vascular and adipogenic stromal cells. Hashimoto Y, Tsuchiya T, Doi R, Matsumoto K, Higami Y, Kobayashi E, Nagayasu T.

J Tissue Eng Regen Med. 2019 Nov;13(11):2067-2076. doi: 10.1002/term.2923. Epub 2019 Oct 23. PMID: 31267683

 

Utilization of Natural Detergent Potassium Laurate for Decellularization in Lung Bioengineering. Obata T, Tsuchiya T, Akita S, Kawahara T, Matsumoto K, Miyazaki T, Masumoto H, Kobayashi E, Niklason LE, Nagayasu T.

Tissue Eng Part C Methods. 2019 Aug;25(8):459-471. doi: 10.1089/ten.TEC.2019.0016. PMID: 31317819

 

2018

Sodium hydroxide based non-detergent decellularizing solution for rat lung. Sengyoku H, Tsuchiya T, Obata T, Doi R, Hashimoto Y, Ishii M, Sakai H, Matsuo N, Taniguchi D, Suematsu T, Lawn M, Matsumoto K, Miyazaki T, Nagayasu T.

Organogenesis. 2018;14(2):94-106. doi: 10.1080/15476278.2018.1462432. Epub 2018 Jun 11. PMID: 29889592 Free PMC Article

 

Adipose-derived mesenchymal stem cells attenuate rejection in a rat lung transplantation model. Watanabe H, Tsuchiya T, Shimoyama K, Shimizu A, Akita S, Yukawa H, Baba Y, Nagayasu T.

J Surg Res. 2018 Jul;227:17-27. doi: 10.1016/j.jss.2018.01.016. Epub 2018 Mar 2. PMID: 29804850

 

An EGFR ligand promotes EGFR-mutant but not KRAS-mutant lung cancer in vivo. Tomoshige K, Guo M, Tsuchiya T, Fukazawa T, Fink-Baldauf IM, Stuart WD, Naomoto Y, Nagayasu T, Maeda Y.

Oncogene. 2018 Jul;37(28):3894-3908. doi: 10.1038/s41388-018-0240-1. Epub 2018 Apr 17. PMID: 29662194

 

2017

Transplantation of bioengineered rat lungs recellularized with endothelial and adipose-derived stromal cells. Doi R, Tsuchiya T, Mitsutake N, Nishimura S, Matsuu-Matsuyama M, Nakazawa Y, Ogi T, Akita S, Yukawa H, Baba Y, Yamasaki N, Matsumoto K, Miyazaki T, Kamohara R, Hatachi G, Sengyoku H, Watanabe H, Obata T, Niklason LE, Nagayasu T.

Sci Rep. 2017 Aug 16;7(1):8447. doi: 10.1038/s41598-017-09115-2. PMID: 28814761 Free PMC Article

 

Gene signature driving invasive mucinous adenocarcinoma of the lung. Guo M, Tomoshige K, Meister M, Muley T, Fukazawa T, Tsuchiya T, Karns R, Warth A, Fink-Baldauf IM, Nagayasu T, Naomoto Y, Xu Y, Mall MA, Maeda Y.

EMBO Mol Med. 2017 Apr;9(4):462-481. doi: 10.15252/emmm.201606711. PMID: 28255028 Free PMC Article

 

2016

Ventilation-Based Decellularization System of the Lung. Tsuchiya T, Mendez J, Calle EA, Hatachi G, Doi R, Zhao L, Suematsu T, Nagayasu T, Niklason LE.

Biores Open Access. 2016 May 1;5(1):118-26. doi: 10.1089/biores.2016.0012. eCollection 2016. PMID: 27186445 Free PMC Article

 

2014

Influence of pH on extracellular matrix preservation during lung decellularization. Tsuchiya T, Balestrini JL, Mendez J, Calle EA, Zhao L, Niklason LE.

Tissue Eng Part C Methods. 2014 Dec;20(12):1028-36. doi: 10.1089/ten.TEC.2013.0492. Epub 2014 Jun 3. PMID: 24735501 Free PMC Article

 

Future prospects for tissue engineered lung transplantation: decellularization and recellularization-based whole lung regeneration. Tsuchiya T, Sivarapatna A, Rocco K, Nanashima A, Nagayasu T, Niklason LE.

Organogenesis. 2014 Apr-Jun;10(2):196-207. doi: 10.4161/org.27846. Epub 2014 Jan 31. Review. PMID: 24488093 Free PMC Article

 

The poly(adenosine diphosphate-ribose) polymerase inhibitor PJ34 reduces pulmonary ischemia-reperfusion injury in rats. Hatachi G, Tsuchiya T, Miyazaki T, Matsumoto K, Yamasaki N, Okita N, Nanashima A, Higami Y, Nagayasu T.

Transplantation. 2014 Sep 27;98(6):618-24. doi: 10.1097/TP.0000000000000305. PMID: 25221900 Free PMC Article

 

2012

Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung. Maeda Y, Tsuchiya T, Hao H, Tompkins DH, Xu Y, Mucenski ML, Du L, Keiser AR, Fukazawa T, Naomoto Y, Nagayasu T, Whitsett JA.

J Clin Invest. 2012 Dec;122(12):4388-400. doi: 10.1172/JCI64048. Epub 2012 Nov 12. PMID: 23143308 Free PMC Article

 

Protein reporter bioassay systems for the phenotypic screening of candidate drugs: a mouse platform for anti-aging drug screening. Chiba T, Tsuchiya T, Mori R, Shimokawa I.

Sensors (Basel). 2012;12(2):1648-56. doi: 10.3390/s120201648. Epub 2012 Feb 7. Review. PMID: 22438730 Free PMC Article